analgesic drug

Detailed Product Description

    Lappaconitine is an active ingredient in the form of white crystal which is extracted and isolated from the roots of Aconitum sinomontanum Nakai. It was proven to be the medicine with extensive applications by the Chinese scientists. Also, it was proven to possess the local anaesthesia, defervescence, antiphlogistic and detumescent effects through 26 years of clinical practice. It can be used to prepare medicine in the forms of tablets, injection (aqua and powder) and patches. It is highly effective for chronic muscular aches, persistent arthritic pain, and pain in cancer patients. This medicine has many comparative advantages over ordinary pain suppressant, the most important advantage is non-addictive and safe with hardly any side-effects. It is also applicable to aches and pain in the common cold and influenza.

     During the original R&D stage, Lappaconitine Hydrobromide was purified to a high content of 99.97% as the standard. Shennong Pharmaceutical uses advanced purifying techniques to offer such high content Lappaconitine Hydrobromide (HPLC purity ≥99.0%) to both domestic and overseas markets. Please direct any enquiries to our Sales Departments.

Chemical name:      (1α,14α,16β)-20-ethyl-1,14,16trimethoxyaconitane4,8,9triol4[2-(acetylamino)]  benzoate hydrobromide mono-hydrate.

Molecular formular and weight:       C₃₂H₄₄N₂O₈ HBr H₂O; 683.64

Properties:       White crystals; odorless; tastes bitter; mp. 217-219; [α]_D +31^o±1 (C, 2; methanol); fully dissolved in methanol, partially dissolved in water, slightly dissolved in ethanol, almost non-dissolved in chloroform.

Pharmacology: Lappaconitine hydrobromide is a non-addictive analgesic drug with relatively strong analgesic effects. Its analgesic intensity is seven times of antipyrine and that is similar to Pethidine, the analgesic effect is delayed but last longer. It has remarkable effects of anti-pyretic, reducing pyrexia, anti-inflammatory and local anesthesia.

Toxicology:       Animal test showed no aberration, teratism, and carcinogenic side effects. Acute toxicology test showed that LD₅₀ in mice (mg/kg) was 9.1 for i.p. and 6.9 for i.v.; LD₅₀ in rats (mg/kg) was 20 mg by oral injection.

Preparation:     Lappaconitine hydrobromide injection; Lappaconitine hydrobromide tablets.

Purity: It contains no less than 99.0% of C₃₂H₄₄N₂O₈ HBr, calculated on the dry basis with HPLC method. analgesic drug..